The mass-mailer approach necessitates "cost-cutting, going to bars, meeting for coffee the first time," he added, "because you only want to invest in a mate you're going to get more out of".
As more and more people ditch their landline for whatever reason no need for it anymore, crappy economy necessitates cost-cutting, etc. these companies have to come up with ways to offset the loss.
Still, the stark lack of infrastructure and basic services in these rural areas has necessitated cost-effective interventions in malaria prevention and control.
There is an urgent need for a cost-effective, broad-spectrum HPV prophylactic vaccine in developing countries, which necessitates substantial cost subsidization of the virus-like particle (VLP) based vaccines licensed in industrialized countries or an alternative approach with second-generation vaccines that are specifically designed for delivery to women in resource-poor communities.
The lack of forthcoming NCR products may be due to logical business models that necessitate the cost effective development of new products due to the needs of the marketplace.
Given our limited sequencing effort necessitated by cost constraints, these numbers compare well given the estimate of ~14,000 genes in D. melanogster [ 59, 60] and suggest we have captured slightly less than half of the genes present in the genome.
Furthermore, determination of the drug susceptibility profile for drugs to be used as preventive treatment for MDR contacts poses both technical and logistic challenges and may lead to drug-related harms, which would necessitate additional cost for close monitoring which has resource implications [ 31].
"Stemming [the market share losses] could necessitate price cuts, or increased commercial costs, potentially thwarting management attempts to attack the overall cost base".
You say a "dirty" bomb -- a bomb that uses conventional explosives to spew potentially lethal radioactive material -- could contaminate "a wide area" and while probably not causing many deaths, would necessitate cleanup costs and other effects like those after the Chernobyl nuclear accident.
In resource-limited settings, competing financial priorities necessitate low-cost medical models.
