Sentence examples for necessitates combining from inspiring English sources

This situation necessitates combining homology-based searches, structure-based approaches and manual curation for fungal helitron searches, as described in this paper.

27 The effective management of psoriasis frequently necessitates combining therapies in order to achieve optimum response while minimizing any side-effects.

However, the discrepancy between promoter methylation and MGMT negativity necessitates combined immunostaining and methylation specific PCR.

The typically poor prognosis of such infections is (besides delayed diagnosis) predominantly due to the low susceptibility of these fungi to commonly used antifungal agents (Chouaki et al. 2002; Kratzer et al. 2006), which often necessitates combined treatment with different drugs (Kratzer et al. 2006; Alanio et al. 2008).

Second, small sample sizes for some conditions necessitated combining them.

Moreover, an effective inhibition of synovitis and joint destruction may necessitate a combined blockade of the JNK isoforms or even additional MAPKs.

These are compared and reviewed in Baross et al. [58], who concluded that the detection of all real CNVs from a 100K array necessitated the combined use of multiple procedures.

While many of the models consider idealized geometries and are able to provide insights into the underlying mechanisms, it is essential to place such models in an anatomically realistic setting, which necessitates an interdisciplinary approach combining the fields of mathematical modeling, scientific computation, and medical imaging.

While the IPEBA is summarised in Figure 1, Table 1 summarises the underlying limitations of each of the four study types that together necessitate an iterative approach combining all four types, as well as how the combination of these studies in the IPEBA can address these limitations.

Many cancer cells develop resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL -induced apopTRAIL -inducedtapoptosisbinecessitatinghemotherapy, and normal combinationest side effects due to the combined treatment regimen of TRAIL and chemotherapeutic drugs.

This global emergence and propagation of clones combining methicillin resistance and PVL toxin production necessitates commensurate counteraction with improved vigilance, enhanced case ascertainment, and effective management of PVL-related disease.