The nonlinear bearing force- and stiffness-displacement characteristics in combination with the bearing clearance necessitate an advanced numerical analysis.
In Europe, where tighter clearances necessitate smaller body dimensions and track is not designed for axle loadings as high as those accepted in North America, the payload capacity of similar four-axle cars is between 60 and 65 tons.
Management of urolithiasis necessitates a balance between stone clearance and morbidity related to the procedure.
In accordance, in our study endotracheal suction was performed more often in patients in the routine group compared to patients who received on demand MH, suggesting improved clearance of secretions necessitating airway suctioning.
The enhanced tumour accumulation, reduced normal tissue to blood ratios and potentially reduced immunogenicity of fragments after PEG attachment may therefore prove superior to either unmodified fragments or intact antibody for antibody-targeted therapy, although the increased plasma half-life may necessitate the use of a clearance mechanism.
This large interindividual variance in parasite clearance responses will probably necessitate relatively large sample sizes for adequate precision using this approach to dose finding.
They act more like a selective "sieve" or a "leaky bucket" than a "tube", which necessitated evolution of a variety of effective clearance mechanisms since the lung cannot rely on 'flow-through' or transit processes, as in the case of the digestive tract.
However, the slow tumor uptake and plasma clearance of mAbs in men necessitate the use of long-lived radioisotopes for imagining at the expense of increased radiation dose to the patients [ 43].
However, HA undergoes rapid clearance due to limited adhesion, which necessitates frequent instillation.
Pre-existing hepatic disease may alter the metabolic clearance of some antidepressants and may necessitate dose adjustment [ 134].
Sampling or sentinel node biopsy may provide an alternative to axillary clearance but a positive sample may necessitate further surgery or radiotherapy with the potential for greater morbidity.
