Limited resources necessitated choosing key informants rather than drawing from a large sample within each organization, so we selected individuals whom we expected would be most involved with innovation at a strategic level and/or were implementing innovations on the ground.
For example, in a GWA study of 500,000 SNPs, a complete two-locus interaction scan of the genome necessitates C2 (500,000 "choose" 2) or ∼125 billion tests.
As was the case for our crosses, this is a considerable improvement over normal success rates and our experience suggests that this was due to the great attention paid to choosing parents necessitated by the high cost of making these wide crosses.
This freedom of choosing data formats necessitates the development of several pattern recognition templates in the form of regular expressions to handle diverse formats (co-ordinates separated by space, comma, tab etc).
The practical application of anatomical research to clinical problems necessitates special adaptation and selectivity in choosing from numerous international works.
"Doctors do not dispute that the economic crisis necessitates difficult decisions but Mr Darling is choosing the wrong target and using the wrong weapon.
Choosing this kind of pet necessitates you to get registered with a virtual pet adoption website so that you can acquire a pet.
This study necessitates walking over the chosen route several times in each direction to complete and verify on the spot information obtained in previous reconnaissances.
Since there are 28 proteins in this core network, even choosing only one ligand to inhibit each of these 28 proteins would necessitate 28 ligands, which may be unsuitable for wet-lab validation.
In general, choosing an appropriately sized geographic domain will depend on a variety of factors, including the timescale of analysis, dispersal capabilities of the organism, and whether analytical constraints necessitate that all focal species share a common domain.
