Sentence examples for necessitates assumptions from inspiring English sources

Whether a forward or inverse approach is used, the estimation of parameter values necessitates assumptions regarding the functions or rate laws that describe the reactions of interest.

But this scenario is not parsimonious, because it necessitates extra assumptions of secondary loss and/or gain of invertebrate (molluscs and crustaceans) and vertebrate hosts during the divergence of major groups of the Neodermata.

1, 4 This limitation necessitates an assumption of good correspondence between dispensation record and drug intake.

Therefore, using the results as lifetime cost figures necessitates the assumption that no major deviations from 2005 conditions occur.

Although we have attempted to address some sources of uncertainty in this analysis, our results still necessitate several assumptions.

The addition of other states would necessitate greater assumptions, which would increase complexity but not necessarily the accuracy as additional bias and uncertainty is also increased.

First, as with all prescription databases, there is no information on adherence to prescriptions, which necessitates an assumption of good correspondence between prescription record and drug intake.

This method was used for two reasons: first, it is unclear how a response should move a subject along the growth curve, and such a process would necessitate further assumptions.

While skepticism of the utility of PBPK models exists to some degree, because of lack of understanding of some aspects of the system properties, necessitating various assumptions and judgments, future efforts in PBPK modeling and simulation should focus on improving the "facts" or evidence, that is the science of presenting mathematical and mechanistic "truths".

In part this concern is addressed by the analysis depicted in Fig. 6, and this shows that a non Na+ pumping origin of the V/F/A-ATPases necessitates the assumption of convergent evolution or gene transfer, but it is not "at least 6" independent events, but only at least 2 independent events that survive closer scrutiny.

While the model also necessitated many assumptions about the water distribution system (for example, that all users drew the same amount of water), results from validation studies show good correlation between our exposure estimates and PCE concentrations in historical water samples (Spearman correlation coefficient = 0.65, P < 0.00010) [ 21].