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It follows that such a reaction necessitates both acid-base and redox properties of a catalyst the acid site being of Lewis type (cations) and the basic sites being the surface O2- or OH- species which could exhibit electrophilic or nucleophilic properties.
In contrast to the aryl umpolung reaction, the iodonium strategy, however, necessitates a deprotection step after the F-exchange.
Control over reactor stability and product distribution necessitates a thorough study of the strongly coupled turbulent flow and reaction processes in chlorination reactors.
The poor aqueous solubility of paclitaxel necessitates a large percentage of Cremophor EL:ethanol (USP) in its commercial formulation which leads to hypersensitivity reactions in patients.
It necessitates a battle plan.
An alarm necessitates a pat down.
That necessitates a phone call, rather diminishing the blink concept.
Stability of pyrolysis oils necessitates a two-step processing.
That necessitates a near-addiction to the news.
High-office bigotry also necessitates a jarring cultural adjustment.
But it necessitates a rethinking of old ideas.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com