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Structural enzymology necessitates a complete structural characterization, even for highly homologous proteins (greater than 80% sequence homology), as every active site has distinct structural features and it is these active site differences that distinguish one enzyme from another.
A key step in the rational design of new RNA binding small molecules necessitates a complete elucidation of the molecular aspects of the binding of existing molecules to RNA structures.
Thirdly, across both quantitative and qualitative approaches, capturing the economic (and social) complexities surrounding the use of technology can be challenging, because it generally necessitates a complete understanding of the manner and magnitude of change in the clinical management pathway associated with treatment and follow-up.
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This philosophy would necessitate a complete change in corrections, including the way budgets are allocated and prisons are built.
Europe's leaders recognised that a more peaceful future would necessitate a complete reorganisation of the politics, economics and even the national identities of the continent.
In a few cases, negative comments and feelings moved postgrads to seek new supervisors – in one case, even where this necessitated a complete change of research focus.
But ensuring that no one is held in jail based on poverty would, in many respects, necessitate a complete reordering of criminal justice.
The grim reality since 9/11 has necessitated a complete revamping of emergency plans for governments and corporations alike, and the plans in place at our nation's nuclear plants have often served as models.
In October she played a devastating late-night set during the #Offline Festival, the Pitchfork-sponsored counterprogramming to CMJ, one that necessitated a complete re-evaluation of her capacities.
Harold was eventually shown to be correct by the use of photo enhancement and laser imaging in the late 80s, necessitating a complete rethink about the dating of many other key Athenian texts.
The fall, which took place only days before the orchestra was to leave on its first tour under Levine's direction, might have necessitated a complete change of program (conductors equally happy in Beethoven and Carter are just about as rare as ivory-billed woodpeckers) had it not been for the availability of David Robertson.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com