Sentence examples for necessitated the expression from inspiring English sources

Of note was the fact that increased LN dissemination necessitated the expression of RasG12V in the cells as well as supplementation of CM derived from cells expressing hyper-activated Ras and stimulated by TNFα (=CMRasG12V+TNFα).

This step necessitates the expression of genes involved in the Bone Morphogenetic Protein (Bmp) signaling pathway (in mammals, Bmp2 and Bmp4) which activates cell differentiation, but also the Hedgehog and Fibroblast Growth Factor (Fgf) signaling pathways which induce proliferation and counteract the Bmp pathway [ 7– 10].

The growing number of microarray expression datasets has necessitated the integrative analysis approaches to identify significant molecular patterns across multiple datasets.

The diversity of β-subunit expression patterns found in cardiomyocytes necessitated the functional characterization of each β-subunit isoform.

The company said its cost-reduction plan necessitated the resignations.

The assassination of Vice President Luis Argana early last year necessitated the election.

The factors which necessitated the armed struggle still exist today.

La Russa said soaring star salaries necessitated the change.

That necessitated the NE and SW corners being completely reworked.

That necessitated the additional round.

This necessitated the use of another model.