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Calculation of the Peto odds ratio did not necessitated the data of 5 out of 9 studies included in the second meta-analysis.
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The generation of high-complexity microarray data has necessitated the development of novel data analysis methodologies that can cope with data of this nonlinear and highly dimensional nature.
Model inputs for epidemiology data were obtained from Chinese studies to the greatest possible extent; however, the paucity of epidemiological pneumococcal disease studies in China necessitated the use of data from other countries, especially from East Asia (Table 1).
However, evident over-dispersion in the data necessitated the use of a quasi-Poisson link function.
The limited resolution of the data necessitated the use of strict non-crystallographic symmetry restraints throughout refinement; however, by using the Rfree as a guide, we were able to model small differences between the RCL of each molecule by loosening restraints in this region.
The use of multiple biological replicates necessitated the evaluation of the data to assess reproducibility and account for batch effects, i.e. experimental variation caused by sub-groups of measurements that are not related to the underlying biology of the system being studied.
This change from physical documents to digital files has necessitated the creation of large data sets and consequently the transfer of large amounts of data.
The evaluation and comparison of such massive amounts of surveillance data necessitated the construction of a computerized infrastructure organized in such a manner that it would assure not only data storage and retrieval but also an eventual bioinformatics analysis.
The biological interpretation and simultaneous statistical analysis of these complex data necessitated the development of new representation and analysis tools, which was achieved using custom Perl scripts [ 18, 20].
The recent move from lead to lead-free soldering by the electronics industry has necessitated the generation of material properties data that will allow accurate prediction of the lead-free solder's performance under vibration conditions.
The availability of massive amounts of GWAS data has necessitated the development of new biostatistical methods for quality control, imputation and analysis issues including multiple testing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com