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The fully quantitative nature of the qRTPCR results allows comparison of mRNA levels between different ER isoforms and of variant levels between tumours, but necessitated selection of optimal cut-points (in this case using ROC analysis) for the dichotomization required for standard outcome analysis.
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Pluripotent stem cells (PSCs) have various degrees of pluripotency, which necessitates selection of PSCs with high pluripotency before their application to regenerative medicine.
Moreover, in daily life, there are many moving objects necessitating selection of a specific target, which includes the decision of whether to pursue or not.
While the time series tools do not indicate a preference for one particular latency, the same linear coefficients produced do not necessitate selection to provide an interpretation of the relationship between SC and SN.
We expect that in natural communities, adaptation to newly encountered microparasites or changes in microparasite virulence occurs on ecological rather than evolutionary timescales, necessitating selection based on pre-existing genetic variation, referred to as 'standing genetic variation' (Barrett and Schluter 2008).
Indeed, the scarcity of favorable winds along major migration routes (Gauthreaux et al. 2005; Kemp et al. 2010) apparently necessitates selection of nonsupportive winds (Alerstam et al. 2011; Alerstam 2011) Similarly, compensation for incident or previous wind drift may or may not be necessary or advantageous.
Size increase has been accompanied by many mechanical requirements that have necessitated a selection for increased efficiency; the result has been a great increase in the complexity of organisms.
In addition, the large size of a number of our data sets (e.g., human, rat, and mouse) necessitated the selection of a random subset of the training sequences in order for the program to run in a reasonable time.
We could have chosen a cutoff on these probabilities to define change points, but it would have necessitated the selection of an arbitrary threshold value, while using the regresion model with the highest posterior probability to determine change points can circumvent the problem.
Sarkar has made a similar claim, arguing that, contrary to the claims of pluralists, cases of frequency-dependence, such as in heterosis and in game-theoretic models of selection, necessitate selection at higher than genic levels because the relevant properties of the entities at the genic level are only definable relative to higher levels of organization.
Due to the volume of content received, human users must typically skim their timeline of received content and exercise judgement in selecting items for consumption, necessitating a selection process based on heuristics and content meta-data.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com