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The difference in standards also necessitated maintaining different formulations, different quality standards and duplicating staff.
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Ionic strength was maintained at 200 mM for all Pi concentrations, although for 30 mM Pi this necessitated decreasing the total creatine phosphate concentration from 25 mM to 17.5 mM.
The patents listed in the Orange Book and the strategy of using patents to maintain market share have also been recognized as an important lesson from this example since it has necessitated consideration of a patent strategy whenever new forms (polymorphs, hydrates, solvates, salts, cocrystals, amorphous solid dispersions, etc).
Maintain, maintain, maintain.
Well maintained?
The impending global water crisis has necessitated practices to conserve and replenish our existing water resources.
Playing safe necessitated tangential allegories.
This necessitated installing air conditioning, generators, electric cables and toilets.
It therefore necessitated vigilant and often violent defense.
The need to recoup such costs necessitated long film runs.
I know you have moved into playwriting recently - was that necessitated by politics?
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