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The extensive discussion on the possible roles of these genes, necessitated given the lack of known function, is totally speculative and would benefit from a shorter and more focused treatment.
He would have expressed his own meaning more perspicuously had he spoken instead of "the minimum content of positive law, the minimum set of principles which, because rationally necessitated —given certain fundamental 'truisms' about human nature and the human predicament for the securing of purposes shared by all survivable human societies, can be called natural law".
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We tested potential interactions between the independent variables by adding pair-wise product terms between them to the "main effects only" model to check if any given product term necessitated inclusion.
Valspodar has been shown to decrease the clearance of etoposide, doxorubicin, paclitaxel, and vinblastine, and these interactions have necessitated dose reductions of the anticancer agents when given as single agents in combination with valspodar (Boote et al, 1996; Giaccone et al, 1997; Fracasso et al, 2000; Bates et al, 2001, 2004; Chico et al, 2001; Minami et al, 2001).
SMR04 records contain information on patient demographics such as personal identifiers, age and sex; the diagnosis that necessitated the admission; and the aspects of the care given such as the psychiatric subspecialty admitted to.
(GP, female, 38 years old) Travel and cost: Participants (15) were conscious of the difficulty some patients faced when they were advised to see a dentist that necessitated travel to a regional centre, acknowledging that this was 'expensive' and given that travel could be '200 km each way' on occasion 'almost impossible'.
The impression given is that modern Canberra is Griffin's city, with a few changes necessitated by modern life, of which he would have approved.
This practice, however, has been a common means of establishing a new, high-profile account's worthiness and authenticity, something Twitter almost necessitated due to its otherwise opaque procedures for having a Twitter account "verified" (i.e. given a seal that indicates the person is who they claim to be).
There is even a sense in which free choices are necessitated namely, it is necessary that human beings, given their nature as conscious rational beings, make free choices, though it is not necessary that they choose this rather than that.
In any case, even if the student is doubtful about the correctness of her understanding, we, at the least, can safely presume that the need-driven explanations are a kind of default explanation given by the students9 that is, when no other convincing explanation is available to them, they are most likely to understand the change as necessitated by the "need" or the "conditions" of the time.
Thus, although low prevalence settings provided opportunities for trying out new models of result giving, in some areas urgency of need necessitated rapid implementation before localities were sufficiently prepared to deliver results.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com