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The main toxicity was haematological, with neutropenia and thrombopenia, that necessitated course delay and dose reduction.
Treatment was administered on day 1 of each planned 21-day cycle if the patient's neutrophil count was >1.5×10 l−1 and platelet count was >100×10 l−1; values less than this necessitated a treatment delay until recovery.
Toxicity necessitated dose reductions and/or delay of therapy in all patients.
Any delay of >14 days in any course of treatment necessitated patient withdrawal from the study.
INSIDE PITCH There was more unsettling news for the Mets: Orlando HernÁndez's return to the team has been delayed after he experienced discomfort in his right foot that necessitated an examination Tuesday in New York.
Her entrance into service was delayed by accidents during sea trials, including a collision with another vessel that necessitated major repairs.
A delay of >2 weeks for haematological recovery or further significant haematological toxicity after two dose reductions necessitated patient withdrawal from the study.
Playing safe necessitated tangential allegories.
This necessitated installing air conditioning, generators, electric cables and toilets.
It therefore necessitated vigilant and often violent defense.
The need to recoup such costs necessitated long film runs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com