Sentence examples for necessitated a dose from inspiring English sources
In all cases, in each group where toxicity necessitated a dose reduction, delay or study treatment termination, the patient was followed up until the event had resolved.
Furthermore, grade 3/4 diarrhoea and dehydration requiring hospitalisation in another phase II study evaluating capecitabine and oxaliplatin necessitated a dose reduction of capecitabine from 2000 to 1500 mg m−2 for 14 days every 21 days.
Grade 3 stomatitis in cycle 2, necessitating a dose reduction, was observed in one patient.
This procedure may necessitate a dose reduction due to increased toxicity as a result of prolonged exposure to methotrexate [ 3].
Adherence to interferon therapy was difficult even in patients who did not experience side effects or did not necessitate a dose reduction.
28 When coadministered with the sodium bicarbonate solution, 10 CFU S. Typhi (Quailes strain) gave an attack rate of 55%, necessitating a dose escalation to reach the target attack rate of 60 75%.
When comparing the five different references consulted to identify necessary drug dose adjustment in relation to the estimated kidney function, we found that the number of drugs that necessitate a dose adjustment in case of renal impairment differ considerably (Table 5).
The dose-limiting toxicities (DLT) were defined as (i) any grade 3 or 4 non-haematologic drug-induced toxicity excluding alopecia, nausea or vomiting, (ii) any haematologic toxicity necessitating a dose reduction and (iii) any drug-induced adverse event that warranted removal of the patient from the study.
Factors that necessitated a reduced dose were progressive primary disease, many lesions, poor performance status, adverse effects, and patient inconvenience during EBRT.
One patient developed grade 3 PPE at cycle 2, which was treated symptomatically and resolved by cycle 3, but necessitated a subsequent dose reduction to 45 mg m 2.
Withdrawal symptoms or rebound symptoms may occur after ceasing treatment abruptly following a few weeks or longer of steady dosing, and may necessitate a gradual dose reduction.
