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Natural history studies necessitate validation of an automated, high-throughput method for HPV genomic DNA detection in oral rinse samples (ORS).
Subgroup analysis produced results using relatively small sample sizes; therefore, these findings necessitate validation on larger patient cohorts.
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It is important to note that the small sample size, necessitates validation of these candidate gene expression changes in a larger cohort.
Molecular diagnostics have, in this respect, the advantage of being both sensitive and easy to integrate in laboratory practice, but the lack of morphological proof of a signal necessitates validation experiments.
This will necessitate rigorous validation in clinically annotated specimens with long-term follow up.
This would necessitate additional validation studies under both controlled laboratory conditions and actual occupational operations.
We made this change to improve clarity, but concluded that it is not substantial enough to necessitate additional validation at this time.
The heterogeneity of patients between studies might necessitate a validation and a comparison of available CDRs in a single paediatric population.
Moreover, high-throughput techniques like microarrays are associated with limitations such as experimental and biological noise that necessitate further validation of the results obtained using other relatively accurate methods.
It necessitates further validation by the retrospective analysis of surgical series in terms of implant survival.
Consequently, the MAM process is poorly understood and build-process simulations are computationally demanding; this limits the availability of Design for Additive manufacturing (DFAM) tools, and necessitates experimental validation for commercial MAM applications.
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