However, several critical defects of those traditional drugs, such as modest therapeutic effects, severe side effects and extremely high costs, necessitate the development of novel therapeutic agents.
The high mortality of invasive fungal infections, and the limited number and inefficacy of antifungals necessitate the development of new agents with novel mechanisms and targets.
Shortages of donor kidneys for transplantation necessitate the development of advanced therapies and devices to effectively treat kidney diseases.
Compound contamination and toxicity interaction necessitate the development of models that have an insight into the combined toxicity of chemicals.
The disastrous consequences of ship collision necessitate the development of a collision risk-informed assessment procedure that ensures safety and functionality of maritime transportation systems.
Rapid advances in entertainment technology necessitate the development of computational models for interactive plots capable of creating engaging stories that are meaningfully interactive.
However, adverse effects and ineffectiveness of most of these medications especially in the management of steroid resistant severe asthma necessitate the development of better medications.
The limitations of established serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake inhibitors necessitate the development of safer and more effective therapeutic agents.
Such concerns necessitate the development of realistic, flexible and tractable models of SREC prices that capture the behavior of participants given the rules that govern the market.
Higher turbine inlet temperature requirements in modern gas turbine airfoils necessitate the development of high performance internal cooling designs for increasing turbine durability and performance.
The incorporation of random geometric variations, however, potentially could necessitate the development of thousands of nearly identical solid geometries that must be meshed and separately analyzed, which would require an impractical number of man-hours to complete.
