Hippocampi with major defects were excluded from further analyses as they were few, could easily be identified, and would necessitate manual editing in order to be analysed, which was not the focus of the present study.
Software-associated difficulties with automated bone and implant identification necessitate manual analysis in some cases, which inevitably leads to a reduction in precision (Spittlehouse et al. 1999).
A total of 2,245 URLs were not accessible during the initial run, thus necessitating manual review.
This was particularly true for those without electronic systems, thereby necessitating manual chart audits to identify those due or overdue for vaccinations [ 23, 26- 28, 31, 32].
Anatomical variation makes the fibula more or less separable from the tibia, especially on the LA scans, and also frequently necessitates manual override in the analysis.
Datasets of predicted proteins produced by the sequencing consortia often miss homologs, and predicted proteins contain mispredicted exons and introns in many cases, necessitating manual assembly and annotation.
Applying heat to activate dTrpA1 causes changes in refractive index, which disrupt focus, necessitating manual focus correction in the cases where we used this technique.
A closed-mouth position necessitates manual segmentation to separate the teeth from each other, which was a tedious, time-consuming, and user-dependent procedure that resulted in unsatisfactory results.
But a search for p53 in the nucleotide database at NCBI [ 4] results in a list of more than 5700 accessions (over 285 pages), which necessitates manual curation to find the specific accessions of interest.
Traditionally, extracting free-text information has necessitated manual coding (where a researcher reads free-text and codes it by hand according to a defined set of coding rules) [ 8], which is time and labour intensive and therefore, not always feasible on a large scale.
Both BAC clones had areas of reduced quality reads with low or no sequence coverage bordered by regions of low complexity sequence repeats, which necessitated manual curation of the sequence assembly resulting in substantially improved sequence assemblies of two (PGB02) and one (PGB04) contigs.
