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Of note, the success of our cancer therapeutic approach requires that FE-Pro-labeled NSCs retain their tumor-targeting ability and expression of the therapeutic transgene, but does not necessitate differentiation or long-term intra-parenchymal integration of FE-Pro-labeled NSCs.
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Here we report a primary elastofibroma that developed at the subscapular port site after thoracoscopic surgery for lung cancer, necessitating differentiation from port-site recurrence of the cancer.
"It is only through existence that the facts are manifest … and nothing requires that this body have this or that particular structure … the perpetuation of the species does not necessitate sexual differentiation … [while] it remains true that both a mind without a body and an immortal man are strictly inconceivable … we can imagine a parthenogenetic or hermaphroditic society" (390, my emphasis).
If the former is true, this would indicate that there is a restricted period of plasticity in the regulation of myelin sheath number by individual oligodendrocytes and that new myelin made at distinct periods of life would necessitate the differentiation of new oligodendrocytes.
Thirdly, comparable deficits should be observed when patients are required to process complex visual stimuli (familiar or novel) that necessitate high acuity/spatial frequency information for differentiation.
They concluded that dynamic MR indexes were useful in the differentiation between SPNs that necessitated further evaluation or treatment (malignancy and active infection) and SPNs that did not necessitate further evaluation or treatment (benign nodules).
Indeed we found that selection for Oct4 was of limited utility over the time course of monolayer differentiation, with high background necessitating multiple rounds of replating.
Collectively, this data enhances our understanding of regulation of hESC differentiation by miRNAs, yet necessitates further support in additional targeted experiments.
Furthermore, another methodological limitation in this study is that measuring neglect/emotional abuse in early childhood is particularly difficult as the awareness of it necessitates the development of a degree of differentiation and autonomy, which is seldom the case with psychiatric patients.
On the other hand, with the onset of differentiation, the development of neuritic projections necessitates a rise in the relative contribution of membrane proteins, so that the increase in the membrane/total protein ratio gives an indication of augmented membrane "complexity".
The total protein/DNA ratio rises with cell enlargement and, with the onset of differentiation, the development of neuritic projections necessitates a rise in the relative contribution of membrane proteins, so the increase in the membrane/total protein ratio gives an indication of augmented membrane "complexity".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com