They ask the player to fully engage with their devious designs, with difficulty spikes that necessitate full concentration to overcome.
Working with screaming hot glass (2,250 degrees, to be exact — roughly three times hotter than a pizza oven) necessitates intense concentration; there is the very real danger of handling a molten material, but also a finite window of opportunity within which the glass is workable.
These experiments also served to emphasize one point about the use of transporter KO mice to study CP transport; that is, unless the transporter is expressed only in CP (or unless a tissue specific KO is used), there may be alterations in plasma substrate concentrations between the null and wild-type which necessitate referencing tissue concentrations to the plasma concentration.
They ask the player to fully engage with their devious designs, with difficulty spikes that necessitate your full concentration.
This leads to unwanted side reactions which could lower the radiochemical yield (RCY) or necessitate a higher concentration of the precursor for the subsequent coupling reaction.
The establishment of the centrally planned economy and society required by socialist ideology necessitated an enormous concentration of power.
An increase in reactant temperature reduces the heat-sink effect necessitating a higher concentration of sand to extinguish the flame.
This is particularly true in cancer treatments because cancer cells upregulate their expression of multidrug resistance transporters, which necessitates a higher concentration of extracellular drug to promote sufficiently high intracellular concentrations for cell killing.
Newer studies demonstrating that many of these compounds are quite active at very low concentrations necessitate examination of this question to determine if these multiple actions pose a greater health hazard.
This suggests that CaM-peptide may bind CaM at the site of interaction of W-5, but that CaM-peptide has a higher affinity necessitating a high concentration of W-5 (haloga log more than the IC50 of 210 µM) (20, 40) to inhibit binding of CaM-peptide to CaM.
Because of the large difference of the IgG concentrations between serum and CSF, comparison of the avidity results necessitates independence of IgG concentration.
