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The advantages of using mass spectrometry associated with an unfinished genome to identify immunogenic proteins, compared to other approaches such as phage display library [34], [35], comparative genomic [36] or systematic expression of all ORFs [37], resides mainly in the minimal necessary workload and in the rapidity of the method.
This decrease in the number of NEMS points needed has a direct effect on the necessary workload in the different AR and length-of-stay models.
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Further research is necessary on workload differences among GPs (including part-time work) and on practice costs: what elements are included and what are the determinants of the extent of these costs.
Even when the cost of whole genome sequencing breaks the much-anticipated $1000 threshold, the necessary computational workload could still remain burdensome and limit its widespread implementation outside major genome centres.
There were a number of significant changes in long bone, especially femoral, cross-sectional morphology and asymmetry among females through time that probably reflect increases in the workload necessary to produce surplus crops.
Later on, methods employing microsatellite-enriched genomic libraries diminished costs, time and workload necessary for marker development [ 5- 7].
The necessary information on workload, clothing worn, worker's time-activity pattern and acclimatisation was collected on-site, to make appropriate adjustments to the measured WBGT value.
An imbalance between the muscular workload necessary to generate the required inspiratory pressure and the maximal pressure-generating capacity has been implicated as a major contributor [ 41] to this failure.
Tumor volume has been proven to be an important prognostic indicator for a variety of tumors, although the extra workload necessary to perform manual tumor volume measurements on MRI images have limited its applications in clinical routine.
Furthermore, we used the average NEMS points for all patients (minus the patients with diagnosis 15) in the EURICUS database as an indicator for the nursing workload necessary for the non-ILI acute-care patients.
In a long-term perspective, a shift away from polyclonal antibodies towards alternative reagents, which can be produced at constant quality, would help to reduce the necessary financial and workload efforts associated with quality control of polyclonal antibodies and ensure sustainability (Bradbury & Plückthun, 2015a; Bradbury & Plückthun, 2015b).
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