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Rheumatoid Arthritis (RA) can be detected in human skeletal remains, and likely originated from the Americas and spread to Europe after the pre-Columbian era ended, possibly by a microorganism or allergen that is a necessary trigger for the disease [7].
However, PPARδ stimulation in combination with physical activity induces the expression of a suite of metabolic genes, improves endurance performance, and reduces fat content, which indicates that exercise is a necessary trigger allowing PPARδ to interact with otherwise cryptic target genes [13].
An adverse event should not be a necessary trigger for change of practise.
Recently, Wang et al. [ 39] postulated that viral infection of the tumor tissue generates the necessary trigger that activates an acute immune response against the tumor tissue.
This transient genetic blocking experiment suggests that innate immune cells and the wound inflammatory response are a necessary trigger for recruitment of melanoblasts and melanocytes to sites of tissue damage.
The evidence seems consistent with the idea that the appearance of a new immunogen is a necessary trigger for oncogenesis and that immunity may continue to stimulate the growth of a cancer throughout much of the tumor's existence.
Similar(54)
Analysts questioned whether the surprise cash call was necessary, triggering speculation that it could herald a big acquisition.
The necessary triggering event will be a big telecom bankruptcy or two to clear the field.
We make use of MIH function and services to generate the necessary triggers and events in our architecture.
It's a big concept with many nuances, but in the end, using it well allows you to make the necessary triggers and connections with your customers.
The innate immune response is the body's first mechanism for defense against pathogens and is capable of inducing inflammation and, if necessary, triggering the adaptive immune response.
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