In fact, we recommend that any study should consider undertaking simulations on a single chromosome to evaluate the necessary thresholds for their particular study design, especially if several window-based tests are anticipated.
Here, we have explored the impact of the choice of MAF threshold and the choice of test statistic on the necessary thresholds for window-based tests, and have shown that these factors have different patterns of dependence and will impact necessary genome-wide thresholds.
Using a glenosphere with a 10-mm lateralized center of rotation, hybrid baseplate fixation maintains micromotion below the necessary threshold for bony ingrowth.
In the case of lymphoma, it is possible that the observed reduction in PtdIns 3,4,5) P3 levels may not be sufficient to dampen signalling below the necessary threshold for growth inhibition.
Based on work performed in laboratory dogs as well as pharmacokinetic sampling from dogs in the Phase I study [ 3, 7, 8], 3.25 mg/kg of toceranib given EOD provides sustained plasma drug concentrations at or above 40 ng/ml, the presumed necessary threshold for receptor inhibition in vivo as established in rodent studies [ 4].
As we consistently observe a much lower STAT3 activation by IL-27 in hepatocytes and hepatic stellate cells compared to IL-6 one can also speculate that the STAT3 activation after IL-27 stimulation does not reach a necessary threshold for efficient induction of STAT3-dependend genes such as SOCS3.
So quite how R&D of a decision-support app also constitutes 'direct patient care' — the necessary threshold required for sharing data without explicit patient consent, in this instance — remains unclear.
At the end of the (far too short) "SeKT" project, we were able to define reference conditions and necessary toxicity thresholds for the various sediment contact tests [8] and succeeded in categorizing polluted sediments in terms of their toxicity [9].
In Figure 4, the necessary significance thresholds for controlling FWER at 5% are shown for genomic sections of varying size for this combined strategy.
These numbers are then empirical estimates of the (−log of the) necessary significance thresholds for FWER = 5%, for genomic pieces of varying sizes corresponding to the different sections; equivalently, these are empirical estimates of 0.05/ m e (after antilog transformation), where m e is the effective number of independent tests.
The party was just 0.3% short of the necessary threshold to secure Bundestag representation for the first time.
