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In these instruments the necessary specificity of the drug imaging experiment can be reached by measuring the precise mass of the drug.
Interfering signals of similar mass in MS mode usually yield different MS/MS signals, so the necessary specificity of the measurement is achieved.
It is therefore necessary to ensure the necessary specificity of detection of a particular, probably small signal in between many other signals.
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A possible explanation for this could be deficient homing of cells with necessary specificity to the tumor site [32].
As the specificity of HDACs for particular histone types tends to be low [ 9, 48], it is likely that the absence of VPA-induced acetylation of certain H3 and H4 lysines across Hoxb loci reflects the absence of catalytically-active HATs of the necessary specificity, rather than variations in HDAC levels or types.
However, none of these have progressed sufficiently to provide the necessary specificity and sensitivity required for clinical implementation.
For spermatozoa there are no available data; there is no information on what concentration of compound enters the sperm cytoplasm, whether there are pumps effectively making high external concentrations necessary, the specificity of the sperm PDE complex(s) or which complexes are present (see below).
It is still necessary to demonstrate specificity of findings, i.e. that early onset MD are of specific etiological importance to ED and do not simply increase the risk of later psychopathology in general.
While this is necessary for the specificity of the prediction, lower TSS read counts are still reasonable when assessing the expression level of a TU.
HuR does not act in isolation and interplay of HuR with other proteins and miRNAs is necessary to obtain specificity of interaction with these mRNAs.
When polyomavirus VLP ELISAs are used to diagnosis cross-species infection, such as SV40 infection in humans, competitive inhibition assays are necessary to verify specificity of the response.
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