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This may indicate that ZtCBR1 is not only an alternative redox partner for CYP51 in Z. tritici but that it is necessary for its function.
The amino acid chain then spontaneously folds to generate the three-dimensional shape necessary for its function.
Since B49 binds to the BST-2 extracellular domain, we hypothesized that internalization of B49 is not necessary for its function.
Comparison of anti-adhesion activity of B49Mod1 to parental B49 shows that removal of CPP does not have effect on the ability of B49Mod1 to inhibit adhesion (Fig. 2D), indicating that peptide internalization is not necessary for its function.
Beclin-1 is known to contain a leucine-rich NES that is necessary for its function in autophagy [23].
This boundary element consists of five protein binding sites, all of which are necessary for its function.
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Thus, our data support the notion that loss of function of both copies of the PKD1 gene are necessary in order for its function to be inactivated.
Different phosphorylations by ERK1/2 and JNK probably regulate the function of Bim and translocation of the molecule from the dynein complex in cytosol to mitochondria is necessary for its apoptotic function in some cell lines.
Application of TrypAT showed significantly shorter occlusion times than AT (485 ± 79 s), which were comparable to that in controls, indicating that the GAG binding is being considered responsible for the observed anti-inflammatory capability of AT but is also necessary for its anticoagulant function.
These phosphorylations appear to be necessary for its biological function to set up a characteristic heterochromatic structure [11], [14].
The construct MUC1*1110, truncated after only forty-five (45) amino acids of the extracellular domain, may represent the minimal region of MUC1 necessary for its oncogenic function.
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