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What is necessary for extension?
These results suggest that further engineering of the adhesive is unlikely to dramatically decrease the bow of the bonded system as would be necessary for extension to large form sizes. Therefore, efforts should focus on new flexible substrates and rigid carriers; the model developed here can be utilized as a screening tool for this purpose.
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The P-47's greatest contribution to Allied victory was arguably as a long-range bomber escort in Europe, though delays in developing and fielding jettisonable external fuel tanks (necessary for range extension) limited the plane's impact in this role until early 1944.
More recent studies have identified another key transcription factor, Ume6, which is necessary for the extension of germ tubes into hyphae [27].
Since eed1Δ cells showed a strong and significant down-regulation of UME6, recently shown to be necessary for the extension of germ tubes into hyphae [27], we focused further experiments on the genetic interactions between UME6 and EED1.
Sir2p is a NAD dependent histone deacetylase that has been reported as being necessary for lifespan extension via DR in budding yeast [14], although controversy about its role as a master regulator of DR in yeast remains [9].
These results indicate that sir-2.1 is not necessary for lifespan extension by sDR.
This result indicates that AMPK and FoxO are also necessary for lifespan extension induced by another method of restricting nutrients.
Of note, activated PCP signalling is necessary for convergent extension of proliferative chondrocytes, which contributes to rudiment morphology.
Vimentin is an intermediate filament protein that is important for neuronal growth/development and is necessary for the extension and branching of neurites [ 74].
Table S1 AMPK/ aak-2 and FoxO/daf-16 are necessary for lifespan extension by sDR across a gradient of bacteria.
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