Sentence examples for necessary for efficacy from inspiring English sources

It is still unclear whether high levels of cytokine production may be necessary for efficacy of an rCTL agent and what the clinically tolerable level of cytokine release might be (Lum and Thakur, 2011).

This standard is tarnished by the expense and the long period sometimes necessary for efficacy to be evident (1 3 months in most studies).

Behavioral effects in the TST are often seen after acute treatment with SSRIs, even though chronic treatment is often necessary for efficacy in human patients.

In fact, the published experience with epratuzumab in lymphoma, in which cell killing is presumably necessary for efficacy, suggests that this agent has only very modest capabilities when used alone and unaltered.

Interestingly, the HuCNS-SC-mediated impact on cognition and synaptic and growth associated markers occur within a relatively short time post-transplantation (4 6 weeks), when most donor cells are still relatively immature, suggesting that a specific differentiation program may not be necessary for efficacy; rather, intrinsic properties of HuCNS-SC may be more relevant in these models.

At present, these arguments are all speculative, as the levels of BACE1 inhibition and Aβ reduction necessary for efficacy in humans are as yet unknown, although insight into these parameters might be gleaned following analysis of the results from the ongoing clinical trials.

Although antibody medicines show excellent efficacy in therapy of such diseases, they have some disadvantages, for example, repeated injection maybe necessary for maintaining efficacy, risk of anaphylaxis, and decreased effectiveness due to the anti-antibody response in the hosts.

In vivo administered MNPs are quickly challenged by macrophages of the reticuloendothelial system (RES), resulting in not only neutralization of potential MNP toxicity but also reduced circulation time necessary for MNP efficacy.