Sentence examples for necessary for differentiation from inspiring English sources

This epigenetic variation may be necessary for differentiation, but it also provides a mechanism for Darwinian evolution at the cellular level that may underlie age-related diseases such as cancer.

Gabaldón et al. ([2005]) demonstrated that Nitric oxide (NO) production was necessary for differentiation of TEs derived from Z. elegans mesophyll cells.

Thus, the withdrawal of IL-6 mediated STAT3 signaling may be necessary for differentiation to occur.

Since IL-6 was rapidly down-regulated prior to this time it is worth suggesting that IL-6 may be intimately involved in the proliferative process and the absence if IL-6 may be necessary for differentiation to occur.

From a tissue engineering[6] perspective, appropriate spatial, temporal and mechanical cues are likely to be necessary for differentiation of ESC-derived progenitors capable of generating functional substitutes for damaged or diseased tissue [2], [3], [7], [8].

In embryonic stem cells, PcG proteins regulate stem cell pluripotency by maintaining repression of alternative lineage genes that are necessary for differentiation of stem or progenitor cells into various tissue types [35].

Further, mitochondria undergo dramatic remodeling during the differentiation of keratinocytes, which is necessary for the differentiation [ 64], and dysfunctional mitochodria can accelerate keratinocyte differentiation without inducing apoptosis (v).

Skeletogenic transcription factors control molecular fingerprints of chondrocytes and osteoblasts; Sox9 is required for chondrocyte differentiation, while Runx2 is necessary for osteoblast differentiation [ 15].

However, Lhx1 is a necessary factor for differentiation of several tissue types as Lhx1 −/− embryos die ∼ E10 (Shawlot and Behringer, 1995).

This group may contain genes necessary for G differentiation, but not necessary for Mk differentiation, but may also contain anti-apoptotic genes affecting Mk apoptosis or preventing G apoptosis.

In addition, the presence of surrounding nonspecific cell types may influence the cell differentiation path; thus, pure populations are necessary for controlled differentiation.