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In wt αB crystallin, the 3D organization of the interactive sequences may be necessary for coordinating their collective activity in response to cell stress and in control of microtubule assembly during cell proliferation.
We also now mention that Tol and CpoB may have additional/other roles during PG synthesis (please see the subsection headed "Why is PBP1B tuning necessary for coordinating septal PG synthesis and OM constriction?").
The reviewers expressed concern about the relatively weak phenotypes of a cpoB deletion, and we now address this explicitly in the Discussion (in the subsection headed "Why is PBP1B tuning necessary for coordinating septal PG synthesis and OM constriction?").
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In addition to repressing the expression of several collagen transcripts, we also found that FoxO was necessary for the coordinate increase in the gene expression of matrix metalloproteinase 8 (Mmp8) and Mmp9 in muscles of cachectic tumor-bearing mice (Table 2 and Additional file 3: Table S1), which participate in the degradation of Type I, II and III collagens and Type IV collagens, respectively.
It provides the central services for coordinating the components necessary to load, start, and carry out a test.
Since it is usually not safe to assume that concurrently signaled errors are independent, some means for coordinating error recovery are necessary.
We would also like to acknowledge the work of Sarah Wall and Jennifer Parrish for coordinating and implementing the recruitment protocol necessary for this study.
PTP-PEST, along with FAK and Src, is required for coordinating the dephosphorylation and phosphorylation of focal adhesion proteins, which is necessary for promoting focal adhesion turnover and stimulating cell migration.
Re-evaluation of the output was necessary for those coordinates that present 2 or more candidate SNVs.
For Affymetrix data, both log and Z-transformation are required in Step 1: The log-transformation gives data a more symmetric distribution, and Z-transformation itself does not affect the individual t-statistic for each gene and is necessary for transforming the coordinate axes.
Here, they track real-time conditions in the city, when necessary coordinating a response to emergencies and disruptions.
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