Any disjunctive notion that entails notion of harm at (III) as a necessary condition for causing harm will fulfill this requirement.
Geographically, disease distribution or occurrence can be perceived either as the locations where cases are found or as the places where the necessary circumstances for causing illness are prevalent.
In other words, biological interaction means that joint presence of the genetic and environmental factors is the necessary condition for causing disease.
The quintessence, well secured in several cases for the greater safety of those who have to handle and transport it, should be sent to the commander-in-chief that he may take the necessary steps for causing it to pass into the enemies' hands.
This, of course, is just what would be predicted by a model of complex multifactorial etiology, but it emphasizes that we are not finding genetic variants that are necessary and sufficient for causing dyslexia.
Activation of JNK is reported to be necessary for apoptosis caused by different compounds of garlic in some cell lines (Filomeni et al, 2003; Xiao et al, 2003).
In particular, the TNF-related apoptosis inducing ligand (TRAIL) receptor can activate JNK, although this effect is not necessary for apoptosis caused by this receptor suggesting other pathways are activated [ 61, 62].
Whether antiviral treatment is necessary for ALF caused by severe acute hepatitis B needs further extensive studies, but the obstacle is big because a randomized trial in the setting of severe acute hepatitis B seems unethical.
The small number of longitudinal studies emphasizes the lack of longitudinal research, and further prospective studies are necessary for determining cause and effect and the type (correlation, mediator and moderator effect) of the interrelationship among physical activity, physical fitness and overweight.
