The fact that the isolated HOXA9 moiety (HOXA9ΔN) had no effect on differentiation shows that the NUP98 moiety is necessary for disruption of human hematopoietic differentiation.
The healing of the wound in the epithelial layer after injury is a necessary process; disruption of this process is known to inhibit regeneration [ 2- 5].
While this phosphorylation event may be necessary for disruption of the dimmer, data suggest that it is not sufficient (See next paragraph).
It calls for well-designed intervention strategies that reduce ineffective and redundant interruptions by maintaining necessary, inevitable disruptions that contribute to patient safety and clinical collaboration [ 14, 25, 26].
However, the EPIYA motifs are not necessary for epithelial disruption because when they are not present, as in CagAEPISA, epithelial disruption still can occur.
"What we built right after the second world war is no longer adapted to this new economy and that makes this disruption necessary.
Cazeneuve's spokesman refused to discuss the precise date the camp would be dismantled, saying discretion was necessary to prevent disruption or attracting large numbers to the camp in its final days or weeks.
As stated above, loss of plantar sensation alone does not necessary indicate nerve disruption and is not an appropriate indication for amputation [10].
