According to Torday et al. (Torday et al., 2003), parathyroid hormone-related protein (PTHrP) expression is necessary for differentiation of mesenchymal lipofibroblasts, which induce ATII cell differentiation making PTHrP receptor transcript levels indicative of alterations in lipofibroblast differentiation.
Since osteopontin was described to be necessary for differentiation of myofibroblasts in vitro [ 8], we examined the differentiation of myofibroblasts in vivo and found less of these collagen-producing cells in OPN−/−-mice.
Although actin filament formation has been shown to be necessary for differentiation of lens epithelial cells [ 15], the significance of alpha-crystallin's interaction with actin in differentiation is not known.
Gabaldón et al. ([2005]) demonstrated that Nitric oxide (NO) production was necessary for differentiation of TEs derived from Z. elegans mesophyll cells.
Thus, the withdrawal of IL-6 mediated STAT3 signaling may be necessary for differentiation to occur.
Signals that can bypass the need for ITAM-adapter signaling to induce the necessary osteoclast differentiation activity for tooth eruption are not known.
Since IL-6 was rapidly down-regulated prior to this time it is worth suggesting that IL-6 may be intimately involved in the proliferative process and the absence if IL-6 may be necessary for differentiation to occur.
From a tissue engineering[6] perspective, appropriate spatial, temporal and mechanical cues are likely to be necessary for differentiation of ESC-derived progenitors capable of generating functional substitutes for damaged or diseased tissue [2], [3], [7], [8].
In embryonic stem cells, PcG proteins regulate stem cell pluripotency by maintaining repression of alternative lineage genes that are necessary for differentiation of stem or progenitor cells into various tissue types [35].
