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The deposition of electrocatalytic metals onto the surface of the semiconductor electrode can provide the necessary catalysis for chemical reactions.
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Together, these strategies explain the enigmatic Co C bond cleavage necessary for catalysis by these enzymes.
Crystal structures and structure-based mutational analysis of RNase HII from Archaeoglobus fulgidus, both with and without a bound metal ion, identify the active site for type 2 RNase H enzymes that provides the general nuclease activity necessary for catalysis.
Although each type folds into a characteristic structure that is necessary for catalysis, there is almost no widely conserved nucleotide sequence even within each type [1], [2], [3].
HU inhibits the activity of RNR by scavenging its free radical necessary for catalysis, and the reduced RNR activity leads to decreased concentration of dNTPs in the cell [35].
We conjectured that conformation 3 is the active conformation necessary for catalysis and that molecules capable of preventing Tyr80 from adopting this conformation could inhibit RTA without direct competition with SRL for binding to the RTA active site.
The serine hydroxyl group might be necessary for catalysis.
The aspartate of the DFG motif (D2357) positions a key Mg2+ ion necessary for catalysis.
Gln73 is required to catalyze the water residue that is necessary for catalysis.
Kinases that lack one or more of the residues necessary for catalysis are likely to be non-catalytic pseudokinases.
Enzyme systems in this superfamily contain either three or four component proteins that are necessary for catalysis.
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