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It is unfortunate that many applied methods do not have a strong underpinning built on, what should be considered necessary, blind-testing.
Blind, blind?
Since this is a pragmatic trial, it is not necessary to blind participants and general practitioners for the treatment allocation.
Note that the validation methods used in this pilot study ((i) leave-one-out cross-validation and (ii) randomly blinding 25% of the data after building the DFA models with the entire data) did not accommodate an independent sample set that would be necessary for blind validation.
If considered necessary, the blinding will be repealed on a patient-to-patient basis and the participants will be contacted directly by the endocrinologist.
We expect that when subjective scores are used then blinding is necessary, or if blinding is not possible some explanation should be offered as to why it was not possible or practical.
Therefore, it is necessary for the blind parameter estimation for CR to efficiently demodulate the signals in hostile wireless channel.
Additional threats included the necessary lack of blinding (all trials) and stopping early for benefit (3 trials) or futility (3 trials).
To determine the correct sampling date it was necessary to un-blind the group assignment after safety assessments were completed 7 d after the second injection.
Further research using biomarker evidence to confirm whether the SPG has been blocked after the local intranasal application of LA, and high quality RCTs with adequate placebo to protect the blind, are necessary to assess the veracity and efficacy of this procedure.
Usually, reductive evolution eliminates functions that are no longer necessary for survival -- think blind cave fish or gutless tapeworms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com