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Patients continued to receive treatment with inhaled corticosteroids as required and were provided with salbutamol/albuterol metered-dose inhaler (100 μg per actuation) as rescue medication to be used as necessary at any point during the trial.
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The biggest problem with the plan, which you can read as a PDF file here, is that Amtrak has no prospect of receiving the necessary funding at any point in the near future.
For example, authors should report if it was necessary to unblind any participants at any point during the conduct of a trial.
"That's not necessary at this point.
But it's necessary at this point.
A bit of perspective is necessary at this point.
"This discussion is absolutely necessary at this point," Sweeney said.
Perhaps the invocation of history is necessary at this point in her career.
But Mr Chirac, unlike Mr Schröder, still accepts that war might be necessary, at some point.
That moment is avoided until it's absolutely necessary, at which point communication among the responsible parties becomes exceptionally nasty.
But he should not be expected to lay out a plan significantly more detailed than he has, because it's not necessary at this point.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com