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Akin to the fraction absorbed (Fig. 3), Formulation D had the lowest initial burst, nearly two to three times lower than the remaining formulations (Fig. 4).
Of the four formulations, Formulations A C show a much larger initial burst than Formulation D. The initial burst value at day 1 for Formulation D was around 7%%, nearly two to three times lower than the 13 20 % drug absorption seen with Formulations A C.
The effect sizes, derived from the logistic regression odds ratios, ranged from nearly two to three times greater than the reference categories.
The most important cause of mortality in diabetic patients is cardiovascular disease (CVD) [ 1] and observational studies have shown that diabetes mellitus (DM) increases risk of CVD nearly two to three folds [ 1, 2].
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Mr. Powell did anyway, losing by nearly two to one.
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The Bush endorsement apparently was of little importance to Louisiana Republicans, who backed Santorum over Romney on Saturday by nearly two to one, 49 to 27.
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Alabama voters chose Mr. Romney as the candidate most likely to defeat Mr. Obama in November, by nearly two to one over Mr. Gingrich and Mr. Santorum.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com