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Therefore, those few neurons ectopically expressing EYFP must have been already neurons or nearly differentiated neurons that happened to express the Plp promoter at the time of tamoxifen treatment.
In addition, we found that a very small number of EYFP+/NeuN+ neurons were already apparent 24 h after tamoxifen treatment, and again those few neurons ectopically expressing EYFP were only found in the cerebellar nuclei region, indicating that they must have been already neurons or nearly differentiated neurons that happened to express the Plp promoter at the time of tamoxifen treatment.
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When G8 positive cells were isolated by magnetic cell sorting and placed in culture, nearly all differentiated into skeletal muscle in serum free medium.
It remains incompletely clear how mutations in these proteins, expressed in nearly all differentiated somatic cells, cause such a tissue-specific phenotype.
While endoreplication and polytene chromosomes are best studied in third instar larva salivary glands and ovarian follicle cells in Drosophila species, nearly all differentiated cell types are polyploid with polytene chromosomes [ 38].
Nearly all of differentiated cells were MAP2+, about 70% 80% cells were ISL1+, and up to 70% of the cells were HB9+ (Figs. 3C and S5A).
CaSR has been reported most highly expressed in well-differentiated regions of colon cancer and nearly lacking in poorly differentiated sites [ 8].
Knocking down Klf4 expression in Mbd3 −/− cells, however, resulted in a marked rescue of the differentiation defect, in that nearly all colonies contained differentiated cells.
Most starkly differentiated are the interpretations of Mantel's protagonist.
The IS 6110 'low copy' isolates were not well differentiated as nearly 85% of the low copy isolates clustered together (Fig 3, Cluster 1b).
During the breeding season, however, the mean semiochemical distances between members of MF dyads were significantly differentiated across nearly all classes (pairwise Ps < 0.001, except for class 0.3-0.4 0.3-0.4ss 0.4-0.5, P = 1.0), increasing systematically with genetic distance.
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