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2. Mutations or mutation series are not connected with conjunctions such as and and or; in this case, the impact is grounded to the nearest detected mutation or mutations (in case the nearest mutations are connected by conjunctions, the impact is grounded to each mutation).
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The other four persistent mutations are near the surface of the enzyme.
These mutations are near the active site of the enzyme and may affect the entrance of the insecticide into the active site [ 5].
It can be seen that the ratio of signal intensities near the mutations were distinctly elevated.
Furthermore, the majority of Class I mutations are clustered near the dimer interface and NADP binding site for structural stability, or are deletion mutations [8].
Both mutations are located near the receptor binding site.
In the near future, patients in whom pathogenic mutations are identified could become potential participants for gene therapy, and thus, identification of efficient and effective diagnostic approaches based on the population genetics specific to the patient will become increasingly important.
However, the finding of decreased hydrolysis in disease mutants was enigmatic given that the mutations are not localized near the catalytic site.
Due to the conservation of the affected residues and their position within or near the C-terminal RRM, both mutations are predicted to have deleterious effects on RNPC3 function, impairing binding to U12 snRNA that could affect U11/12 di snRNP complex stability (Netter et al, 2009).
De novo mutations are not inherited but occur spontaneously near or during conception.
The four known mutations are in the transmembrane domain or near the pore loop.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com