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K-means clustering to generate hydrogen-bond, aromatic and ionic pharmacophores was performed over the grid points associated with the same nearest functional group.
For each gene, we detect its nearest functional partners (NFPs).
Second, we introduce the concept of diffusion distance to detect the nearest functional partners (NFPs) of a gene.
Then after overlaying those gene correlation estimates onto gene networks, by using the concept of diffusion distance, the nearest functional partners (NFPs) of each gene are detected.
Similarly to previous methods, we defined these attributes using the sequential distance between SAP and the nearest functional sites (if greater than 50, set 50 as the upper bound).
Based on this weighted gene network, the functional distance of any two genes are evaluated using the concept of diffusion distance, and the genes with the k smallest functional distance to gene g are selected as its nearest functional partners (NFPs).
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When asked whether he agreed that Utah's chronic homeless population was nearing "functional zero", Road Home executive director Matt Minkevitch replied: "I would differ with that perspective".
PVR is related to lung volume in a bimodal fashion, with resistance to flow being minimal near functional residual capacity.
Children inhaled 20-25 times from the nebulizer starting near functional residual capacity at a flow rate of 0.5 L/sec.
The coevolution of sites surrounding important functional regions may compensate the effects of mutations at these functional sites or near functional and catalytic pockets, thereby maintaining an overall volume or shape for that pocket [ 37].
Second, in flies, those genomic regions most strongly bound by a TF tend to be near the functional target genes, and this TF binding near functional target genes is present in more fruit fly species and is stronger in intensity overall (Bradley et al., 2010; Fisher et al., 2012; He et al., 2011b; MacArthur et al., 2009), which was reviewed in Biggin (2011).
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