Merging is performed by expanding the co-ordinates of the original alignment to include the nearby alignment; analysis of matches, mismatches and indels is then performed on the combined alignment.
By careful selection of family members to be typed, i.e. early breast cancer cases distantly related to the proband and old healthy individuals nearby, segregation analysis will be a powerful tool to assess the clinical significance of unclassified variants in BRCA1 and BRCA2.
They could not date the teeth directly, but analysis of nearby mineral samples and animal fossils indicated the teeth are somewhere between 80,000 and 120,000 years old.
We included nearby genes because linkage analysis often is imprecise.
Analysis of nearby divergent genes has shown that both replication and transcription effects are important for strand bias in a range of eukaryotes [ 7].
An analysis of nearby divergent genes concluded that both replication and transcription effects were important for strand bias in a range of eukaryotes [ 12], a result confirmed by an analysis of the bias in large vertebrate genes [ 13].
In 2006, mutational analysis of nearby genes showed that indeed there was a second gene, granulin (GRN), within the region of chromosome17q21, 1.7 Mb centromeric to MAPT, which had mutations (Baker et al., 2006; Cruts et al., 2006).
That painting is heading to the nearby National Gallery in London for analysis, study and public display.
There have also been major reductions in malaria at the Kenyan coast [9] and in some communities nearby in Tanzania [10], but analysis of hospital records from different parts of Kenya has shown substantial variation in trends, indicating that declines in malaria are not universal [11].
Multiple links to collagenase-related sequences and functions are detected through an analysis of the nearby flagellin and hemagglutinin genes (strain A) in addition to the CNT domains.
