"Tree" for example is represented by an ideograph that might be said to look like a tree, etc. Churchill's "Blood, sweat and tears," can be literally translated in Thousand-Character, buthehe nearest Basic can come is, Blood, face water, and eye water".
Apparently, CAD and HCD fragmentation is dependent on the relative location of the nearest basic residue.
Conversely, CAD fragmentation cleaves on average almost three residues farther away from the nearest basic residue than random.
Jahun General Hospital, approximately 1.5 hours away by vehicle, is the nearest basic or comprehensive obstetric care center to Kadawawa.
The two vibrational fragmentation methods exhibit a bimodal distribution, with HCD consistently closer to the nearest basic residue than CAD for fragments at TMHMM scores ≥0.5 and ≥0.9.
The interaction that drives this mobilization is observed even in the center of TMDs, where cleavage sites are on average ∼10 residues distant from the nearest basic residue.
To provide a null hypothesis, the average distance between randomized cleavages (vide supra) and the nearest basic residue was calculated for all proteins.
In Figure 5b,c, cleavage products are binned by their "relative cleavage site", which indicates the distance from the nearest basic residue to the cleavage site.
The village of Tinishu Wegnaki, in the Hamer district of Ethiopia's Southern Nations Nationalities and Peoples' Region is two hours walking distance from the nearest basic health care facility.
A cleavage 7 residues on the N-terminal side of the nearest basic residue has an enhancement factor of ∼0.5 (∼75% chance of a y-fragment), while a similar cleavage 7 residues C-terminal to the nearest basic residue has an enhancement factor of about −0.5 (∼25% chance of a y-fragment).
At increasing TMHMM score, fragments are farther away from the nearest basic residues (up to 10.1 for CAD at TMHMM score ≥0.9), which is consistent with the scarcity of basic residues in these regions.
