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In cases where the PLM nausea rate was 0, half the value of the lowest-detected PLM nausea rate (0.001) was added to enable calculation of log ratio.
The median reporting ratio was 0.38, indicating that, for half of all observed treatments, the PLM nausea rate was at or below 38% of the medication label nausea rate.
In both aggregate PLM and medication label data, cyclophosphamide had the highest observed nausea rate (Fig. 3).
The doxycycline nausea rate in PLM (27.1%) exceeded the medication label nausea rate (8%) by the largest magnitude, which may be explained by differences in both dosing and indication for use.
The aggregate nausea rate reported in the medication label for mitoxantrone (55%) was higher than that reported in PLM (20.3%).
The median medication label nausea rate of 55% is based on data collected over the course of three clinical trials, one with a nausea rate of 76% (n = 62, dose = 12 mg/m2), the second with a rate of 55% (n = 65, dose = 5 mg/m2), and a third trial where mitoxantrone was administered concurrently with methylprednisolone and had a nausea rate of 29% (n = 21) (Novantrone® [package insert], 2012).
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Fig. 3 PatientsLikeMe nausea rates versus medication label nausea rates.
Nausea rates from pediatric studies were excluded.
Fig. 4 Bonferroni-adjusted confidence internals for PLM nausea rates versus medication label nausea rates.
The reporting ratio of PLM nausea rates to medication label nausea rates was defined for all treatments with non-zero medication label nausea rates.
In total, 60 drugs were identified as having label nausea rates significantly higher than PLM nausea rates, and 10 drugs were identified as having label nausea rates significantly lower than PLM nausea rates.
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