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For the 974 significantly modified gene models, it is useful to look more closely at the nature of the modifications made.
Due to the hydrophobic nature of the modifications, secreted Wnt and Hh are not freely diffusible in their isolated form.
As extensively demonstrated in this report, what distinguishes AD from non-AD samples is the distribution of the isoforms in an isoelectric analysis, not the nature of the modifications.
Despite extensive analysis, our MS procedures failed to determine the nature of the ApoE modifications that may be responsible for these variations in isoelectric focusing; however, not knowing the nature of the modifications does not diminish our claim that the charge-isoform distribution could be a biomarker for AD.
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2. The residue profile of the applied pesticide may have been altered on the basis of the nature of the modification.
Due to the selectivity and covalent nature of the modification, this probe could prove to be a valuable tool for the study of other AgD family members.
Moreover, the selective nature of the modification was proven indirectly by qualitatively comparing the sedimentation stability of suspensions of differently modified samples.
"The nature of the modification to the flies, it's important to stress, is it makes them disadvantageous to their local counterparts in that they can only produce sons.
Their activity was predominantly defined by the nature of the modification of the N-acyl hydrophobic interfaces: N-acyl analogs (class A), urea analogs (class B), N-alkyl analogs (class C, lysosomotropic agents), and ω-cationic-N-acyl analogs (class D, mitochondriotropic agents).
Although in some cases space plays a modulatory effect (itself of interest), in other cases, spatial regulation and control can profoundly affect the nature of information processing as a result of the subtle interplay between the patterns of localization of species, diffusion, and the nature of the modification cascades.
Acetylation is broadly linked with activation, whereas methylation can have either activating or repressing effects depending on the amino acid that is modified and the nature of the modification (mono-, di-, or tri-methylation).
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