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This protocol describes a simple assay that can be used to study the nature of exposure of antigenic epitopes and antigenic relatedness of different intact, native HIV-1 strains.
In establishing this assay, the nature of exposure of antigenic epitopes and the antigenic relatedness of six intact, native HIV-1 virions of clades A, B, C, D, F and G were examined using anti-HIV-1 mAbs directed at epitopes in the V2, V3, CD4bd and C5 of gp120, and in clusters I and II of the gp41 region.
The logistic regression model indicated that needle stick injuries and body fluid exposures are strongly associated with each other, indicating the clustering nature of exposure incidents on groups of HCWs probably based on risky habits and suboptimal SPs compliance.
We used the term aberrant parenting to convey the qualitative nature of exposure in this class.
In addition, the nature of exposure is different from that of other workers.
The cases were primarily men indicating the occupational nature of exposure.
Similar(17)
Further studies are needed to describe the nature of exposure-related ECG changes in rats with cardiomyopathies.
They provide the opportunity to characterize the frequency and nature of exposures in the general population.
Therefore, it captures both the cumulative and chronic nature of exposures.
The development of a biomarker that discriminates these metals thus may help define the sources and nature of exposures.
Last, given the unique nature of exposures in this study population, our results may not be generalizable to other populations, those with lower exposures, or older individuals.
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