Overcoming these barriers would, due to their nature, incur substantial costs.
Instead, by examining a broad set of traits, SE evaluations aim at obtaining a picture of the magnitude and nature of incurred changes to use as a screen for potentially problematic changes and a starting point for further investigations [3].
The number of deletion mutants analyzed is too low to draw any strong conclusions on regions of the chromosome or specific genes being 'undeletable' but we could hypothesize certain classes of genes to be of such an essential nature that incurred deletions would render the pollen or its offspring either inviable or severely retarded in growth and survival.
The discrepancies were very few and, as they pertained to the nature of costs incurred, they were not considered to be significant.
A theory of full error correction may benefit significantly from knowledge of the precise nature of errors incurred, potentially leading to higher thresholds for errors that can be remedied by appropriate error correction.
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Next we attempted to characterize the nature of GM related incurred changes and to obtain a picture of their physiological consequences (Figure 1b).
Costs are classified according to three characteristics: phase of implementation of the intervention, organizational level where costs are incurred, and nature of costs.
However, the SS rule is sequential in nature and hence incurs communication and delay penalties.
First, its retrospective nature may inherently incur selection bias.
After screening for potentially problematic metabolites and identifying those for which there is evidence of safety, we addressed the nature and magnitude of the incurred differences.
