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A previous study on the FAS locus has identified a partially intronic antisense RNA that is naturally transcribed from the first intron of the gene, which was named Saf [ 19].
However, it was not possible to determine whether this result was actually due to downregulation of the ITGA6 mRNA isoform containing exon 22D, as we also detected downregulation of another intronic transcript naturally transcribed in the ITGA6 locus [GenBank: BX537483] that spans the 3' terminal exon of the gene.
Altogether, these results indicate that at least a fraction of naturally transcribed intronic non-coding RNAs may be regulated by common physiological signals such as hormones, and further corroborate the notion that the intronic complement of the transcriptome play functional roles in the human gene-expression program.
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A more definitive evaluation of the ASE phenomenon in TGFBR1 will probably only come with technological and conceptual advances that will allow greater precision and circumvent the need for naturally occurring transcribed SNPs as an obligatory tool.
These small noncoding RNAs are naturally occurring molecules that are transcribed in the nucleus, often under the control of specific enhancers.
What endows this RNA with MDA5 agonistic activity and whether the in vitro transcribed version fully corresponds to that naturally formed in EMCV-infected cells will require further investigation.
After endocytosis, the incorporation of naturally occurring, noncanonical nucleosides (indicated as red dots) into in vitro transcribed mRNA prevents activation of and consequently degradation by endosomal (Toll-like receptors, TLRs) and cytoplasmatic (MDA5, RIG1) mRNA-Sensors, thus being efficiently translated into a functional protein at the cell's ribosomes.
Large vocabulary continuous speech recognition (LVCSR) has naturally been demanded for transcribing daily conversations, while developing spoken text data to train LVCSR is costly and time-consuming.
In April , 1959 former President Harry Truman met for three days with students and faculty at Columbia University, for lectures and spirited discussions that were transcribed and later published under the title "Truman Speaks"—a volume that can, naturally, be found in his library.
An #iframe: (http://news.bbc.co.uk/1/hi/entertainment/7684239.stm) can be heard at the BBC; we've transcribed it below: When I wrote "The Grapes of Wrath," I was filled, naturally, with certain angers — certain angers at people who were doing injustices to other people, or so I thought.
I transcribed it here.
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CEO of Professional Science Editing for Scientists @ prosciediting.com