DRISEE assumes that prior to sequencing, over-amplification from a given start point in the template leads to formation of ADRs, and that sequencing error, not naturally occurring sequence diversity, accounts for sequence variation within an ADR bin.
Our analysis reveals that the presence of conserved artificial sequences, e.g. Illumina adapters, and other naturally occurring sequence motifs accounts for most of the reported errors.
Single nucleotide polymorphisms (SNPs) make up 90% of naturally occurring sequence variation in the human genome and SNPs in genes related to the biological response to ionising radiation may affect clinical radiosensitivity.
How do we identify those variants, or combinations of variants (patterns), that are of importance for the phenotype, given that the functionally relevant variants represent only a subset of the naturally occurring sequence variation?
Rossin coded it so that, as the user descends, the gravity in the landscape decreases algorithmically, according to Fibonacci numbers, a naturally occurring sequence related to the golden ratio.
We propose KeyPoint as a generic approach to screen for induced and naturally occurring sequence variation in selected target genes of mutant and/or germplasm populations.
We also estimated type I error rates on naturally occurred sequence data of Chinese Han in Beijing (CHB) and Yoruba people of Ibadan (YRI) populations of the ENCODE3 project.
Given the overall importance of the α-gliadins in CD we set out to determine the naturally existing sequence variation in CD epitopes as deduced from α-gliadin transcripts from developing wheat grains.
These recent results suggest that progress in our understanding of Gp-9 in fire ants has been hampered by limited knowledge of naturally occurring sequence variation; in even the best studied species, S. invicta, only a handful of individuals from a single site in the native range have been sequenced to date.
This will help avoid confusing naturally occurring sequence polymorphisms with mutations that may be causative.
