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The Tol2 element is a naturally occurring active transposable element found in vertebrate genomes.
The Medaka fish (Orizyas latipes) Tol2, belonging to the hAT family of transposons, is the first known naturally occurring active DNA transposon discovered in vertebrate genomes [ 10].
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Most of the work on LDH-based drug delivery systems has been based on already existing active drugs, while little attention has been devoted to exploring the potential of the encapsulation of naturally occurring biologically active compounds in slow- and controlled-release applications.
Quebrachitol (QCT) is one of naturally occurring optically active cyclitols that has now received considerable attention.
Unfortunately, catalytic efficiency of wild-type BChE against naturally occurring, biologically active -cocaine is too low to be effective.
Quebrachitol (2-O-methyl-l-inositol) (QCT), a bioactive plant constituent, is one of naturally occurring optically active cyclitols that has received considerable attention as a starting point for lead discovery.
On the other hand, the topical use of these naturally occurring plant active principles is relatively safe, and their side effects reported in the literature are minor, self-limiting and occasional [ 14, 24, 28, 29].
We therefore investigated the effect of the specific EGFR inhibitor gefitinib on the phosphorylation level, signalling and growth of cells expressing the naturally occurring constitutively active EGFR variant EGFRvIII, a low nontransforming level of EGFR and a high transforming level of EGFR.
Isoflavones, a subclass of naturally occurring and biologically active polyphenolic phyto-estrogens, have also been shown to possess anticancer activities.
The antifolates compete with naturally occurring folate for active moieties on folate-dependent enzymes.
The use of l-ascorbic acid (AA), the naturally occurring and metabolically active form of ascorbic acid in humans, to increase collagen production of fibroblasts in vitro dates back to 1970s [17].
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