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It is activated by its natural ligand SDF-1α.
Before docking, the natural ligand and structural water molecules were removed from the crystal structure.
In a combinatorial protein design approach, the natural ligand pocket of a lipocalin was reshaped.
The natural ligand for the GHS-R has been identified recently; it is called ghrelin.
This is the first study to demonstrate that NAGly is a natural ligand for GPR18.
For active EGFR, the absorbed Au10Peptide5 might replace the natural ligand in EGFR endocytosis process.
The natural ligand of NTSR1 is neurotensin (NT), a neuromodulator of the central nervous system.
For Fe(III), the Kcond Fe(III L of a Fe-natural ligand complex and total natural ligand concentration [CL] can be calculated from the intercept and slope of a [Felabile]/[FeL] vs. [Felabile] plot.
Glu is the primary natural ligand of iGluRs in the central nervous system in animals (Traynelis et al. 2010).
In case the scaffold was crystallized with a natural ligand, one could for example select all residues that are within a certain distance from that natural ligand.
The two latter ligands mimic the natural ligand in their capacity to induce ER target genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com