Sentence examples for natural libraries from inspiring English sources

In particular, single-chain antibodies (sFv) have been reported to fold poorly in the reducing environment of the cytoplasm and as such there has been a reluctance to use sFv-phage libraries as a source of intrabodies unless a pre-selection step to identify these rare sFvs from natural libraries or libraries of engineering sFvs that could fold properly in the absence of disulfide bonds were used.

Its natural libraries are the richest.

Mutations in the carboxy-terminal core sequence are often tolerated by modifying enzymes, leading to natural libraries of peptide products [ 4].

We synthesized a "Natural" library and a "Uniform except [Cys] = 0" library mentioned in the previous section.

Structurally, GAGs are polymers of alternating hexosamine and hexuronic acid residues that are variably sulfated resulting in a natural library of millions of sequences.

Examples are: a library with the average amino acid composition of natural proteins [ 24], which is named "Natural" library in this article, the uniform amino acid composition; and the uniform composition except [Cys] = 0.

A single strain, Prochlorococcus MIT9313, contained 29 precursor peptides that could be modified by a single lantibiotic-processing enzyme, leading to a natural library of diverse natural products in these strains.

This is despite the fact that the complexity, functional diversity and druggability of nature's natural product library are considered by many to be superior to any library any team of scientists can prepare.

Hence, the chances to find novel compounds with activity against tumor cells in natural product libraries are higher than in synthetic libraries.

According to this PCA mapping, there is a clear chemical space separation between the screening library and the natural product library.

We and others have used PCA to evaluate the structural diversity of natural-product-inspired libraries, natural products, and synthetic drugs, and to correlate biological activity with chemical structure.