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After statistical filtering, 2,474 expression profiles (2372 microarray and 102 real-time RT-PCR gene expression profiles, data available as supplemental material in Additional file 1) were identified as being characteristic for either natural differentiation (ovarian or testicular differentiation) or androgen-induced masculinization (trans-differentiating gonads).
They may have been formed as a result of natural differentiation of the layers of Lias stone and clay used by farmers during the Middle Ages as terraced hills to make ploughing for crops easier.
As we show for retinoic acid, natural differentiation is slow, even if OCT4 and NANOG are rapidly downregulated.
Addition of troglitazone to WT cells did not significantly alter their differentiation profile probably due to the natural differentiation potential of these cells (Fig. 7A, B).
Clearance of HPV may be elicited in part by the natural differentiation, migration and exfoliation of infected keratinocytes from the cervical epithelium.
Therefore apart from promoting an NMP state these conditions simultaneously provide an environment for the production of the natural differentiation products of NMPs.
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In addition, we used araC, an inhibitor of mitosis and potent inducer of apoptosis [25], as a structurally related drug with no direct epigenetic activity, and retinoic acid as a natural differentiation-inducing agent.
However, most of the studies performed thus far were focused on a very small number of well characterized genes, proteins or hormones and mostly on natural gonadal differentiation.
Surprisingly, most of the genes over-expressed during natural testicular differentiation were not restored by the androgen-induced masculinization suggesting that the inhibition of female gonadal development is the main required step sufficient for building a testis.
Other physiological roles for MerTK in hematopoietic cells, include natural killer-cell differentiation and platelet aggregation.
In contrast, no reduction in this motif was reported during natural killer cell differentiation.
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